Gainesville Commissioner Chase says of Stephen Foster Neighborhood, “In a million years, I wouldn’t live there with my kids.”
7 OctResident Farinda O’Steen: “I’m up to 20 in my family that have died over that (Koppers) plant and I want out of the neighborhood”
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- Categories Beazer East, Death, EPA Corruption, Florida, Gainesville, Koppers
National Institute of Health (NIH): Dioxin exposure causes transgenerational health effects
27 SepIn a WSU press release, Skinner said of his latest findings, “It is not just the individuals exposed, but potentially the great-grandchildren that may experience increased adult-onset disease susceptibility.”
By Brant Hamel
A new study, funded in part by NIEHS, found that dioxin affects not only the health of an exposed rat, but also unexposed descendants through a mechanism of epigenetic transgenerational inheritance.
The study was conducted in the laboratory of Michael Skinner, Ph.D., a professor in the Center for Reproductive Biology in the Department of Biological Sciences at Washington State University (WSU) who designed the study. Co-authors included assistant research professor Mohan Manikkam, Ph.D., research technician Rebecca Tracey, and postdoctoral researcher Carlos Guerrero-Bosagna, Ph.D.
“Although not designed for risk assessment, these results have implications for the human populations that are exposed to dioxin and are experiencing declines in fertility and increases in adult onset disease, with a potential to transmit them to later generations,” the authors concluded.
Dangers of dioxin last for decades after initial exposure
Dioxin, 2,3,7,8-tetrachlorodibenzo[p]dioxin (TCDD), is a chemical compound that constitutes part of the Agent Orange herbicide used as a defoliant in the Vietnam War. According to research cited in the study, exposure is estimated to have caused 400,000 deaths and 500,000 birth defects. Dioxin has also been released from industrial accidents, leading to human exposures. Due to its extremely long half-life of up to 10 years in humans, dioxin may still affect pregnancies occurring even 20 years after exposure.
In the Skinner group’s experiments, exposure to dioxin caused changes in the DNA methylation patterns of sperm that were transmitted across generations, in an imprinted-like manner, to affect the health of multiple generations of descendents. The grandchildren of exposed rats showed dioxin-induced effects ranging from polycystic ovarian disease to kidney disease. The work raises the serious concern that even if toxic chemicals, such as dioxin, were completely removed from the environment, they could continue to cause disease for multiple generations.
Health effects of dioxin include early onset of puberty in females
Skinner’s group used low in vivo doses of dioxin, so that toxic effects were not expected. Female rats were exposed while pregnant, and both their direct progeny and descendants two generations removed were examined.
Although the most prominent phenotypes were kidney disease in males and polycystic ovarian disease in females, a number of other effects including abscesses, colon impaction, lung abnormalities, and missing testes were also observed in animals from the dioxin-treated lineage. Additionally, females from the dioxin-exposed lineage experienced the early onset of puberty. Conversely, males showed delayed puberty, suggesting sex-specific effects of exposure. Early puberty in humans has increased over recent decades and is believed to have an environmental link.
Dioxin alters methylation patterns in germ line DNA across generations
The researchers were able to identify 50 specific regions of DNA that were differentially methylated in the dioxin-treated animals. These regions were permanently reprogrammed and protected from DNA methylation, in a manner that allowed them to be passed down across generations. In the future, these regions may serve as biomarkers that would allow early detection of exposure and risk for disease.
Other chemical compounds, including bisphenol A, phthalates, the insecticide DEET, and the jet fuel JP8 have all been shown to promote disease across generations, through a similar mechanism of epigenetic transgenerational inheritance (see story). This pathway of disease propagation exists not only in rats, but also in humans, mice, worms, flies, and even plants. Thus, future research will be needed to see if other environmental compounds may also lead to health effects across generations.
In addition to NIEHS, NIH and the U.S. Department of Defense provided support for the study.
Citation: Manikkam M, Tracey R, Guerrero-Bosagna C, Skinner MK. 2012. Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations. PLoS One 7(9):e46249.
(Brant Hamel, Ph.D., is an Intramural Research Training Award fellow in the NIEHS Laboratory of Signal Transduction.)
http://www.niehs.nih.gov/news/newsletter/2012/11/science-dioxin/
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Koppers Consent Decree is Irrelevant to Relocation of Residents
9 SepSuperfund Communities across the US who achieved relocation for their families continue to advise Gainesville Koppers Victims and Refugees that relocation was achieved well after consent decrees were signed. They further stress that this is the time to begin really advocating loudly for our families’ relocation out of dioxin-arsenic-pah deathtrap contaminated homes.
Beazer East is certainly not a good neighbor- in fact, there are numerous instances where infamous Dow Chemical is a far better neighbor and citizen than Beazer East.
In July 2012, DOW Chemical offered to purchase 50 dioxin contaminated homes in Midland, Michigan to enable families near the Tittabawassee River Superfund Site to move out of harm’s way. Residents and government agencies did not initiate these offers- Dow undertook this humanitarian action on its own.
Contrast this with Beazer East’s cold-blooded treatment of residents in Gainesville’s Superfund Community: not only has Beazer East failed to reach out to families who need to evacuate their dangerously contaminated homes- residents, many with catastrophic illnesses known to result from chemical exposure, who contact Beazer East with buyout negotiation requests have been uniformly turned down by Beazer East representatives.
Dow Chemical also bought out homes on contaminated land near their Morrisonville, Louisiana plant in order to create a safety zone. Louisiana environmental officials noted that industrial facilities and residences do not mix. Likewise, superfund sites and residences do not mix. Dow executives said buyouts were a sensible approach to moving people out of harm’s way, and good citizenship.
Just this summer, chemical corporation Sasol North America announced plans to introduce a Voluntary Property Purchase Program in Mossville, Louisiana. Mossville residents have been fighting for relocation since at least the 1990’s, so this is huge news for this community whose health and property values have suffered for decades and yet was denied Superfund designation by EPA 2011.
There are many more precedents for relocation buyouts in contaminated communities, including Superfund Communities. Beazer East can choose to be a good neighbor in reality and introduce a buyout option so help their victims get their families out of toxic homes instead of perpetuating the collusion and coverup that will keep harming Gainesville families. In the meantime, Koppers Victims and Refugees will advocate ever more loudly for relocation out of dioxin-arsenic-pah contaminated deathtrap homes…
Sandra Watts Kennedy
President, Stephen Foster Neighborhood Association, Inc.
09/05/13 remarks to Gainesville City Commission
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